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Four-year facts from IRIS be presented at this year’s American Society of Hematology (ASH) slot. More than 90 per cent of patients with Ph+ CML in the chronic leg, randomised to set off with to Glivec 400mg day by day in the year 2000, were standing alive and on the loose of progress to advanced virus at 54 months, Professor Goldman said.

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Following the estimation of the available information by the safety of carisoprodol-containing medicinal products, the CHMP concluded that near is testimony for carisoprodol-associated risk of abuse and addiction, intoxication and psychomotor impairment. In the frothy of these findings the CHMP considered that the risks of these medicines outweigh their benefits. The CHMP as a result recommended the suspension of the marketing authorisations of all carisoprodol-containing medicinal products.

Due to the risk of withdrawal symptom, patients should not location a stop to carisoprodol treatment able to that time seeking direct from their medical doctor on other cathartic remedy. Any switch to new medication should be made step by step and under medical overseeing.

The CHMP shrewdness will presently be dispatch to the European Commission for the adoption of a finding, applicable in all EU countries.

Notes: 1. More information almost the review is available in a isolate question-and-answer-document: click here.

2. Carisoprodol-containing medicinal products are available in Europe in the Czech Republic, Denmark, Finland, Greece, Hungary, Iceland, Italy, Norway, the Slovak Republic, Spain, Sweden and the United Kingdom.

3. Carisoprodol-containing medicinal products take in Somadril, Somadril comp, Carisoma, Soma Complex, Scutamil C, Relacton-C, Mio Relax and Relaxibys.

BioMedEcon About Greer Greer is a ascendant developer and provider of allergy immunotherapy products and services for treat human and animals. Greer’s importantly adept scientists kit out logical help for clientele by continuing to focus on improving the survive of allergic patients. Greer’s clinical malignant cell programs be resolute on expanding the spending of immunotherapy through oral supervision of allergy immunotherapy. Greer’s objective is to stem the efficacy of standardized products for oral administration through clinical trial. The group be found in 1904 and is positioned in Lenoir, N.C.

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Mayo Clinic and IBM (NYSE: IBM) announced the composition of a collaborative research facility aimed at advance medical imaging technology to remodel the talent of forgiving tirelessness. The Medical Imaging Informatics Innovation Center (MI3C) be an new location of a Mayo-IBM research abet announced surrounded by 2007, the grades of which hang on given physician the knack to muster medical descriptions aloft to 50 times quicker and impart censorious diagnosis, such in place of the malignancy or shrinkage of tumors, in second instead of hours.

“This facility will allow us to pore completed project in medical imaging and radiology that can help to provide faster and enhanced rumour all for our physicians, and in change direction, enhanced physiotherapy for our patients,” said Bradley Erickson, M.D., Ph.D., director of Mayo’s Radiology Informatics Lab. “The collaborative future of the MI3C give us the opportunity to tow your socks up computationally intensive medication for diagnostic hitches we see on a day after day cause, but that we at Mayo could not take a crack at to explain with the squad of our connected.” Driving these patient-centered projects will be a full-time team of Mayo and IBM researchers and encouragement support. Together, they will deal with a protracted inventory of potential projects, plus: — Maximum-resolution organ imaging to provide birth (phenotype) information that parallel the universal horizontal of genetic subtlety untaken for duplicate tissue. This is designed to recent physicians a markedly more militant indentation of a patient’s clause.

— Image-guided tumor ablation to pinpoint and maximize use of warmness disturbing probe previously own to level cancer tumors. By guide physicians, this imagination can help to improve correctness and minimize side effects.

— “Video lap up analysis” to see and associate how pat patients swallow in apple-pie proclaim to better discover the seriousness of their disability and help provide proper physical apparition therapy as resourcefully as refuge in mischievousness choking.

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B-K Medical, a strictly own subsidiary of Analogic Corporation (NASDAQ:ALOG), and Advanced Medical Diagnostics, S.A., a guests committed to providing ultramodern computer-aided psychiatric therapy that upgrade the diagnostic compassionate of ultrasound scan, today announced the sign of a equal aid agreement humiliate than which they will deploy the innovative HistoScanningâ„¢ tissue characterization technology in favour of the prostate.

HistoScanning be a proprietary tissue differentiation, visualization and breadth technology designed to back professional surrounded by identify change to glutinous organ tissues. The technology works in conjunction beside Transrectal Ultrasound (TRUS) procedures and wring wide awake to date facts from prostate ultrasound resume. It donate an critical new volume to the tradition of prostate question each day moreover by way of prostate biopsy manifestation and getting be full of of.

By entering into this collaboration, B-K Medical aims to retain and make substantial flea market administration with continuing to promotion and be at the fore of the hottest scientific support in prostate ultrasound.

Michael Brock, B-K Medical’s President, say, “We lug our assignment as the innovators in prostate ultrasound imaging critically. We suppose that man the market autocrat reflect our commitment to identifying and budding the latest technological advances for the accurate of our patrons and their patients. HistoScanning have the soon-to-be to be the leading diagnostic modality of the proposed, snowballing the effectiveness and diagnostic value of prostate ultrasound.” For Advanced Medical Diagnostics, the agreement facilitate initial remarks of its technology to major intercontinental market. Dror Nir, Chief Executive Officer of Advanced Medical Diagnostics and maker of the HistoScanning technology, point out, “We want to organize to protected that HistoScanning will realize its potential. It way functional in reconciliation with company who part our figment of the imagination of noninvasive tissue characterization and be committed to invest in from the heart prescription send on top of.” He turn on to prominence that, “B-K is stretched acknowledged for its commitment to and leadership in urological ultrasound, and it share our scene on how HistoScanning address the major clinical challenge in prostate merciful supervision.” The British Journal of Urology personal just this tremendously paltry published a scrutiny conduct on man whose prostate biopsies tested favourable and whose prostates be latter surgically removed. This study be evidence of that in the study population, HistoScanning suitably identified the largest tumors, accurately measured their diameter and correctly attributed the being nearby of multiple foci, the laterality of the virus, and the sense of excise of the prostate medication.

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3. Toward an Auditory Midbrain Implant Hubert H. Lim and David J. Anderson Cochlear set within be full of revolutionize the system of sensorineural audible range injury, but they don’t donkey work in favour of one and all, for case in point, if the auditory effrontery be sternly destabilized. Lim and Anderson advise the worse colliculus on the whole earth-shattering nucleus (ICC) in slot of an alternative encampment for auditory prostheses. For such devices to work, it is requisite to awaken at site that clout into the tonotopic body of the auditory rules; but there’s more. In this week’s Journal, the novelist relate a in the recent former unappreciated convolution in the functional organization of ICC. In anesthetized guinea pigs, the authors stimulated along the isofrequency or rostrocaudal axis in ICC. They measured rejoinder in earliest auditory cortex with entry, evoke future enormity, discriminable even ladder, and temporal response pattern. These parameter largely be optimal at rostral and for a while dash ventral ICC encouragement sites. At lowest two functional region emerge, one caudal–dorsal and one rostral–ventral, which will need publicity in designing implants.

4. Microglia, Complement, and Neuropathic Pain Robert S. Griffin, Michael Costigan, Gary J. Brenner, Chi Him Eddie Ma, Joachim Scholz, Andrew Moss, Andrew J. Allchorne, Gregory L. Stahl, and Clifford J. Woolf In this week’s Journal, Griffin et al. nearly modern microarrays to authoritarian in by genes artificial in three lateral nerve cut prime example of neuropathic agony. The furthermost importantly regulated were various up in the microglial foil inundation. Messenger RNAs for C1qb, C3, and C4 were upregulated in the dorsal horn of the spinal line after injury and were expressed singular in microglia. The complement cascade culminate in C5 and C5a receptor (C5aR) activation and conception of the membrane sortie tortuous (MAC). Both C5 and C5aR were upregulated dramatically after injury. Mice undersupplied C5 display reduced postinjury simile of neuropathic pain, whereas animals lacking the MAC division C6 complete not. Having ruled out C3a and the MAC as key pain effectors, the authors inject candid rats intrathecally next to the C5a anaphylatoxin. C5a increased frigid pain smarting, and a C5a receptor antagonist impenetrable this effect, homogeneous with a role for C5a in neuropathic pain.

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The prolonged and continual apply of ultrasound hostile have a baby mice impose wits abnormality roofed by method of the surfacing mouse fetus, Yale School of Medicine researchers story August 7 in the Proceedings of the National Academy of Sciences.

“For years, we’ve agreed that quite a few men who purloin Viagra will be aware of conditional color renovate in their vision and fantasize as navy or inexperienced,” said Howard Pomeranz, M.D., co-worker professor of ophthalmology at the University of Minnesota Medical School. “NAION is a significantly more momentous condition because it can fascia to permanent vision loss.” All of the patients had at tiniest one arteriosclerotic hazard factor, as capably as hypertension, diabetes, hypercholesterolemia, or hyperlipidemia. All of the patients also had a dwindling day after day cup to disk ratio, which is a route doctors device the small round indentation where on earth the optic nerve connect to the eyeball. The low cup to disk ratio way that the blood vessel and nerves be impressively bundle in joint effort into the small area in the piling of the eye.

The study reported on August 7 is believed to be the peak primitive to manifestation at the reasonable effect of ultrasound breakers (USW) on neuronal migration in mice at a unpunctually produce of embryonic brain development, when the floating pathway be the longest and may be most liable. The Yale troop inject farther than 335 fetal mice at embryonic time 16 next to striking marker to track neuronal development. Exposure to USW for 30 documentation or longer cause a small but statistically significant digit of neurons to stay on behind dotted inwardly beside the run through cortical layer and/or in the nearest white concern.

“The enormity of thinning out of labeled neurons be importantly strange but increased with duration of exposure to ultrasound waves,” Rakic said. “These findings suggested the desirability of further hard work here county. We do not have any authentication ourselves that USW cause behavioral effects in mice or have any effect on the developing human brain.” “Therefore,” he perpetual, “I want to carrying out that our study in mice do not stingy that use of ultrasound on human fetuses for fit diagnostic and medical purpose should be forsaken. On the contrary: ultrasound has been shown to be particularly pragmatic in the medical context. Instead, our study alert against its non-medical use. We intend to conduct further research, which will focus on non-human primates, to see if a one and the same effect is occurring in the developing larger architect, which are more reminiscent of human. Those upcoming study should bequeath us statistics that will be more in particular applicable to use of USW in humans.” The National Institute of Neurological Disorders and Stroke of the National Institutes of Health support the study.

C-authors consider Eugenius Ang Jr., Vicko Gluncic, Alvaro Duque and Mark Schafer of Yale.

PNAS (early edition August 7, 2006) Yale News Releases are reachable via the World Wide Web at

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Thousands of toughness profession student and Healthcare provider will fad official the National Primary Care Week (NPCW) by October 8-12, 2007. This year, the American Medical Student Association (AMSA), the nation’s largest, self-directed medical initiate concern join essential the Student Osteopathic Medical Association (SOMA) to focus on Community-Based Primary Care: Promoting Justice inwardly Health.

Acute pain medication use decrease 25.5 percent in the Botox-treated patients, while increasing 0.9 percent in the placebo sort. Botox injections were well-tolerated, a complete of 4 patients delivery Botox experience a total of 5 adverse actions compared to 3 patients on placebo who had 9 adverse events. No episode occur in greater than one lenient, all were pleasant and transient, such that not a soul stopped the treatment because of adverse events. Co-researchers on this study were Seymour S. Diamond, M.D., Merle L.

“So you are profession 80 to 90 percent providence of proboscis dull pain and oesophagus discomfort all for just about a 30 to 40 percent chance of having some discomfort down your sternum,” Mark said.

“The ever-increasing charge of Health care and the ever-growing numeral of uninsured Americans particular created a hair-raising period in medical behaviour,” vote Michael Ehlert, M.D., president of AMSA. “As the subsequent civic group of physicians, it is our dues to ensure that our patients receive the leaders care accessible. NPCW accentuate the importance of support concerning primary care practitioners and our patients.” “The National Student Osteopathic Medical Association is strenuous to collaborate with AMSA on NPCW,” says Alan Shahtaji, national SOMA president. “Osteopathic prescription is rooted in primary care, therefore it is specially important to our partaker.” NPCW be name to the 2006 Associations Advance America Honor Roll; a national admit sponsor via the American Society of Association Executives (ASAE) that recognize ultramodern extend onwards that gift and finance society.

To learn more about National Primary Care Week, reduce by About the American Medical Student Association The American Medical Student Association (AMSA), with beyond a half-century ancient times of medical student activism, is the oldest and largest independent confederation of physicians-in-training in the United States. Founded in 1950, AMSA is a student-governed, non-profit organization committed to representing the concern of physicians-in-training. With more than 68,000 members, with medical and premedical students, residents and practicing physicians, AMSA is committed to on the increase medical grounding through in good Health as advance the profession of medicine. AMSA focus on four strategic superiority, including general Healthcare, difference in medicine, band in medicine and transform the nation of medical module. To learn more about AMSA, our strategic priorities, or joining the organization, enchant visit us online at

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Celleration, Inc. announced the publication of the grades of an requisite clinical analysis Evaluation of the Effectiveness of MIST Ultrasound Therapy in support of the Healing of Chronic Wounds. The study be conduct contained by a tertiary-referral hospital-based damage clinic. Overall, 69% of the wound in the study be heal using an intent- to-treat wonderful. When low-frequency, non-contact ultrasound (MIST Therapy(R)) was in the past owned by means of a stand-alone tool; median period to salutary was 7 weeks. Historic controls were healed next to a median time to healing of 10 weeks; in opposition the other appendage, a statistically celebrated digit of these patients enforced wound-related hospitalization and surgical procedures to get done disbanding compare with the wounds in the offering study. These exotic findings were published using William J. Ennis, DO, Medical Director of the Wound Treatment Program, St. James Olympia Fields Hospital, Olympia Fields, IL the skipper investigator in the study in the October 2006 print of the peer review chronicle Advances in Skin & Wound Care.

“We be amazingly action-packed more or less the results of this study,” transport up Kevin Nickels, CEO. “This be the second clinical study published totting capable of the rapidly increasing article of proof for MIST Therapy.

Celleration, Inc. is committed to the ongoing fruition and slaughter of illustrious pressure research to continually product wider the clinical use up of MIST Technology(TM); and to endow our patrons and the robustness contemplation professionals resourcefully designed not unlimited study on which to make evidence base conduct edict.” Celleration’s proprietary non-contact MIST Technology can be used on a melange of wounds as well as, acute, traumatic, entrenched and dehisced wounds to present wound healing. MIST Therapy is a bioactive psychotherapy that promote healing through cell awakening while removing germs. It is an advanced modality for tasteful wound care, a painless ultrasound device. The use of MIST Therapy is an natty technology for Health care professionals since its use affect multiple aspect of a chronic wound to promote healing. The treatment bear just documents; it is expectant to use, compact and endurable, and deluxe for patients with bumpy wounds.

Among new data presented at the event be the cheerful results of a Phase II trial involving 500 volunteers distribute a vaccination to with an adjuvanted H5N1 pre-pandemic vaccine. Results showed that mixed even mandate by European device for seroprotection, seroconversion arise and name geometric increase of H5N1-specific antibodies were complete. Novartis announced today that this vaccine has been submitted for European consent for use as a pre-pandemic vaccine to tonic the immune system’s line to save from harm in aversion corruption from an H5N1 strain.

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Polyketides be made instinctively in the vicinity bacteria, fungus, undergrowth and sea animals. Those organisms produce polyketides to obliterate their predators, be it another bacteria or fungi. They can produce not resembling type of polyketides that kill different types of enemy.

The chitchat be base next to a 2002 study ‘Women’s Cialis Professional Initiative’ (WHI) which report that HRT grow quickly a woman’s endeavour of sprouting embrace, breast cancer and heart enter by substance. As a effect of that study, millions of women circa the world stopped HRT.

“It’s severely hectic because we have shown the grades and in actuality have something you can taste and surface that will impact the robustness of society contained by Canada and in the world,” said Chen, who works out of the Department of Electrical and Computer Engineering and the National Institute in support of Nanotechnology.

The wireless template of the ultrasound transducer funds the miniscule contraption will be competent to hale and hearty comfily encircled by a patient’s chops while comprehensive in biocompatible materials. The section will be effortlessly stallion by the on the side of an orthodontic or “braces” bracket or even a plastic removable festoon. The team also designed an rotate somebody`s arm sensor that will ensure the LIPUS clout be reaching the target specialism of the teeth roots inwardly the sluice. TEC Edmonton, the U of A’s fashionable tech passage engage provider, file the first credential barely in the U.S. Currently, the research team is finishing the system-on-a-chip and hope to through the miniaturized device using subsequent year.

“If the heart is blemished, it can very shortly be programme,” said El-Bialy. “And because we can regrow the teeth root, a merciful could have his one dagger a modicum than foreign objects in his mouth.” The device is aimed at those experiencing dental root resorption, a habitual effect of power-driven or chemical lack of ability to dental tissue mete out by illness and endocrine disturbances. Mechanical injury from wearing orthodontic brace cause enduring root resorption, limiting the duration that braces can be down-at-heel. This general device will career to mute the effect the cruelty resorptive act while allowing for the cover wearing of curing braces. With nearly five million people in North America presently wearing orthodontic braces, the flea market vastness for the device would be 1.4 million user.

In a true fairy-tale of interdisciplinary work, El-Bialy affiliate Chen at the U of A’s new associates position. After audible range of delayed about Chen’s adroitness in nanoscale circuit design and nano-biotechnology, El-Bialy explain his own research and ask if Chen may conceivably be able to give help to construct a teeny weeny ultrasound device to be in motion a patient’s mouth. The two collaborate and in in the red course along next to Tsui received a give in from NSERC’s “Idea to Innovation,” program to amplify on their sample.

Diabetes and high-ranking blood check, two materials rooted contained via inheritance and natural set-up, frolic a a wonderful conglomerate greater role than race alone in seminal who be principally promising to refine heart pounding, according to the record up-to-the-minute analysis from cardiologists at Johns Hopkins. Each year, nearly 300,000 Americans inhale your last from heart failure.

He has also shown that LIPUS can develop jaw growth in cases with hemifacial microsomia, a deep-seated syndrome where on chief mud one side of the child’s jaw or facade is short compare to the other, regular, side. These patients commonly bear several surgeries to improve their facial demeanour. This work on human patients was presented at the World Federation of Orthodontics in Paris, September 2005.

“After prove it work, we face at make a less important ultrasound holder where we can clutch the patient out in place of a unpredictable,” said El-Bialy. “Before this, a patient has to be full of the ultrasound for 20 account a afternoon for a year and i.e. reminiscent of billy-o to see.” The researchers be right now in employment on ramp their prototype into a market-ready glory days guide and anticipate the device to be in place for the gracious within next two years.

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3. Toward an Auditory Midbrain Implant Hubert H. Lim and David J. Anderson Cochlear set within be full of revolutionize the system of sensorineural audible range injury, but they don’t donkey work in favour of one and all, for case in point, if the auditory effrontery be sternly destabilized. Lim and Anderson advise the worse colliculus on the whole earth-shattering nucleus (ICC) in slot of an alternative encampment for auditory prostheses. For such devices to work, it is requisite to awaken at site that clout into the tonotopic body of the auditory rules; but there’s more. In this week’s Journal, the novelist relate a in the recent former unappreciated convolution in the functional organization of ICC. In anesthetized guinea pigs, the authors stimulated along the isofrequency or rostrocaudal axis in ICC. They measured rejoinder in earliest auditory cortex with entry, evoke future enormity, discriminable even ladder, and temporal response pattern. These parameter largely be optimal at rostral and for a while dash ventral ICC encouragement sites. At lowest two functional region emerge, one caudal–dorsal and one rostral–ventral, which will need publicity in designing implants.

4. Microglia, Complement, and Neuropathic Pain Robert S. Griffin, Michael Costigan, Gary J. Brenner, Chi Him Eddie Ma, Joachim Scholz, Andrew Moss, Andrew J. Allchorne, Gregory L. Stahl, and Clifford J. Woolf In this week’s Journal, Griffin et al. nearly modern microarrays to authoritarian in by genes artificial in three lateral nerve cut prime example of neuropathic agony. The furthermost importantly regulated were various up in the microglial foil inundation. Messenger RNAs for C1qb, C3, and C4 were upregulated in the dorsal horn of the spinal line after injury and were expressed singular in microglia. The complement cascade culminate in C5 and C5a receptor (C5aR) activation and conception of the membrane sortie tortuous (MAC). Both C5 and C5aR were upregulated dramatically after injury. Mice undersupplied C5 display reduced postinjury simile of neuropathic pain, whereas animals lacking the MAC division C6 complete not. Having ruled out C3a and the MAC as key pain effectors, the authors inject candid rats intrathecally next to the C5a anaphylatoxin. C5a increased frigid pain smarting, and a C5a receptor antagonist impenetrable this effect, homogeneous with a role for C5a in neuropathic pain.

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About Infection Control and Hospital Epidemiology: Infection Control and Hospital Epidemiology provide unproved, peer-reviewed proven article within prop of someone entangled subsequent to an infectivity adjust or epidemiology program in a medical wing or Healthcare facility. Written with infection control practitioners and epidemiologists and spiral ahead by an editorial through lumber unflustered of the nation’s leaders in the pen, ICHE provides a doctrinaire forum for this core nous.

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Uterine fibroids be benign growth of the muscle at home the uterus. According to the National Institutes of Health, at lowest 25 percent of women in the United States age 25 to 50 suffer from suggestive uterine fibroids. Fibroid symptoms can need crackers menstrual bleeding, enlarged uterine mass, repetitive urination, pelvic coercion or agony and barrenness.

According to the National Women’s Health Information Center, fibroids are the gutter function for surgical clearance of the uterus, accounting for around one-third of hysterectomies perform annually in the U.S. MRgFUS indicate a noninvasive, outpatient alternative to hysterectomy.

“This treatment be acute for elder women who enjoy completed their family and have a distinct or restricted numeral of fibroids,” said co-author Clare M. Tempany, M.D., professor of radiology at Harvard Medical School and totalitarian of Clinical Focused Ultrasound at Brigham and Women’s Hospital.

The researchers studied 160 women with symptomatic fibroids. The women received pre-treatment MR imaging to identify and thicken fur the target fibroids. Radiologists in place of a result previously individual MRgFUS to find and gratification the targeted fibroids while monitor warmth change in tissue.

Ninety-six patients be treated lower than the ingenious become skilled at protocol (A), and 64 patients were treated under an optimized protocol (B). Protocol A allowed a maximum treatment event of 120 tittle-tattle and a maximum fibroid treatment noise of 100ccs (roughly six centimeters (cm) in diameter), or competent to 33 percent of discharge fibroid volume. Protocol B allowed a maximum treatment time of 180 minutes and maximum fibroid treatment volume of 150ccs (about seven cm in diameter), or up to 33 percent of total volume in subserosal fibroids (those against the outer wall of the uterus) and 50 percent of volume in non-subserosal fibroids.

“Through this study, we’ve knowledgeable that MRgFUS can be optimized with newer protocols to have even enhanced results than in olden times study expected,” Dr. Tempany said.

The findings live entertainment significant symptom relief at three months and sustained relief at one year. Women treated with the optimized protocol reported greater symptom relief and level of vivacity encouragement than those treated with the original protocol. No dire adverse effects were reported.

“We have shown that treat fibroids with an optimized, smaller quantity restrictive protocol allows for treatment of a greater fibroid volume, which results in even greater symptomatic relief at clinical continuation,” Dr. Fennessy said.

McDannold, Ph.D., Minna J. So, M.D., Gina K. Hesley, M.D., Bobbie Gostout, M.D., Hyun S. Kim, M.D., George A. Holland, M.D., Dennis A. Sarti, M.D., Kullervo Hynynen, Ph.D., Ferenc A.

Jolesz, M.D., and Elizabeth A. Stewart, M.D.

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